Albumin: The next-generation delivery technology

摘要

The therapeutic efficacy of a drug is determined by the ability for site-specific engagement with its biological target. A poor pharmacokinetic profile as a result of degradation, rapid renal clearance or nonspecific accumulation requires enabling technologies provided by delivery science. Two major delivery branches are plasma half-life extension for improved stability and prolonged plasma residence time for long-acting extracellular drugs, and targeted intracellular drug-delivery to maximize organ-specific or intracellular drug-delivery.