Nano-organized shells and their application in controlled release

摘要

In recent years, a great deal of effort has been invested in the development of delivery systems for drugs, enzymes, DNA and in nonpharmaceutical applications [l]. Many biodegradable and bio-compatible materials including polyamides, polyesters and silica-based compounds have been investigated for use as drug carriers [2,3]. These materials encapsulate, protect and stabilize the active pharmaceutical ingredients, often with the aim of reducing the frequency of administration. Nevertheless, the concept of a drug-delivery system continues to evolve in order to minimize the toxic side effects of drugs, to expand modes of their administration and to broaden their application [4]. A significant challenge in system development is the requirement for using large quantities of organic solvents and complicated methodologies in the encapsulation process [5]. Some active agents, such as stabilizing surfactants adsorbed during therapeutic procedures, lead to bioactivity loss and toxicity issues, which hinder their effectiveness [6].