Clinical implications of cognitive impairment in chronic obstructive pulmonary disease

摘要

Chronic obstructive pulmonary disease (COPD) is a prevalent chronic illness that causes significant morbidity and mortality. In a recent study, we found that severe COPD (defined as need for oxygen therapy or activity limitation) is associated with poorer cognition over time [1]. Our finding is consistent with results from other smaller studies that have examined the relationship between COPD and cognition [2,3]. Cognitive decline, in the setting of COPD, can have significant implications on treatment and prognosis. Clinicians need to be aware of these issues when caring for patients with COPD.COPD is a disabling disease that leads to a decline in physical function because of decreased pulmonary reserve and dyspnea [4-7]. The performance of mobility-related activities such as ambulation and housework often decline with worsening COPD. Our finding that cognitive decline occurs more often among those with severe COPD further complicates matters. For patients with severe COPD who are already physically disabled, the additional difficulty with mental tasks can further threaten their ability to live independently.