Rituximab plus CHOP for treatment of diffuse large B-cell lymphoma during second trimester of pregnancy

摘要

A 31 year old woman presented with an enlarged left supradavicular lymph node and without constitutional symptoms at 15 weeks' gestation during her first pregnancy. A Tru-cut biopsy showed a diffuse, large, B-cell non-Hodgkin lymphoma. MRI of neck, chest, abdomen, and pelvis showed enlarged lymph nodes in both the mediastinum and the left supradavicular area and in the fetus (figure 1). Biopsy samples and aspirate of bone marrow did not show infiltration by tumour cells. Haemoglobin was 11-4- g/L, whereas results of all other laboratory tests, induding lactate-dehydrogenase concentrations, were within normal ranges. The patient was therefore diagnosed with stage IIA diffuse large B-cell non-Hodgkm's lymphoma (low risk on the international prognostic index).