Is radiotherapy boost needed in young patients with ductal carcinoma-in-situ?

摘要

The diagnosis and management of ductal carcinoma in situ (DCS) is challenging to clinicians. Partly because of increased awareness of the importance of screening and improved mammographic technique, DCIS is diagnosed with increasing frequency. However, the optimum local treatment is unclear and complicated by the heterogeneity of the disease. In rare cases, DCIS involves large areas of the breast and requires mastectomy. However, most patients have localised DCIS and are candidates for breast-conserving surgery, commonly followed by radiotherapy. A subset of patients for whom radiotherapy can be safely omitted has yet to be defined.1