Inherited cytokine response and risk of lymphoma

摘要

In this issue of The Lancet Oncology,1 a report by the InterLymph Consortium addresses the role of genetic determinants of the immune response in the risk of developing non-Hodgkin lymphoma. The researchers found that the risk of diffuse large-B-cell lymphoma was significantly increased in individuals with tumour necrosis factor (TNF) 308G->A and the interleukin 10 (IL10) 3575T->A polymorphisms. Given the numbers of cases (n=3586) and the methods used, this study clearly overcomes the limitations of smaller non-population-based studiesthat assessed the distribution of such single-nudeotide polymorphisms in patients with lymphoma.