Phellinins B and C, new styrylpyrones from the culture broth of Phellinus sp.

摘要

Many fungi have the ability to synthesize pigments including caro-tenoids, quinones and styrylpyrones. Among the Aphyllophorales, the styrylpyrone pigments are strictly restricted to Hymenochaetaceae including Phellinus and Inonotus. It is interesting to note that several mushrooms, which belong to the genera Phellinus and Inonotus and produce styrylpyrone pigments, have been used as traditional medicines for the treatment of gastrointestinal cancer, liver or heart diseases, and stomach ailments without the presence of toxic side effects. Recently, the number of novel styrylpyrones with different biological activities from the fruiting body and mycelial culture of Phellinus and Inonotus spp. has been rising sharply. Previously, we reported on four major antioxidants, hispidin, hypholomine B, 3,14'-bihispidinyl and 1,1-distyrylpyrylethan isolated from the culture broths of fungi Phellinus linteus and Inonotus xeranticus. Based on the findings of this study, it was suggested that these pigments might have an important role in the biological activity of these fungi. In addition, we recently identified new prenylated styrylpyrones, phelli-nins Al and A2, isolated from the culture broth of Phellinus sp. KACC93057P and suggested that these were a new group of a natural polyketide-isoprenoid hybrid compounds.