Microwave-assisted rapid synthesis of poly(glycerol-sebacate) elastomers

摘要

Poly(glycerol-sebacate) (PGS) was introduced a decade ago as a potential material for soft tissue repair. All of the proposed copolymerization reactions in the literature include a two-stage (prepolymerization and curing) synthesis where the reaction times can take as long as several days. This study, on the other hand, proposes a new route that eliminates these disadvantages and enables a rapid synthesis of PGS elastomers via microwave-assisted prepolymerization in minutes instead of days. No purge gas, catalyst or vacuum is needed in the first prepolymerization step. The curing stage was carried out at 150℃ for 4, 8, 16, and 24 hours. The glass transition temperature (T_g) and melting temperatures for the glycerol and sebacic acid fragments (T_(m_1) and T_(m_2)) of these PGS elastomers were found as -35.61 ℃, -15.82 ℃, and 61.70 ℃, respectively. The Young's modulus and tensile strength values were found as 0.50 ± 0.02 MPa and 0.27 ± 0.06 MPa, respectively.