Influence of the position of two dehydro-amino acids residues in the oligopeptide sequence on the binding ability towards Cu(II) ions

摘要

Studies on the binding ability of bis-dehydro-hexa- and pentapeptides have shown that the hexapeptides bind CU+2 with similar efficacy as pentapeptides. The increase of distance between two dehydro-amino acid residues in the peptide backbone has no impact on the efficacy in metal ion binding. The type of isomeration [(Z) or (E)] has an influence on the coordination of the metal ion only to the first amide nitrogen. (c) 2005 Elsevier Ltd. All rights reserved.