Copper(II) complexes with 4-amino-alpha-(t-butylaminomethyl)-3,5-dichlorobenzyl alcohol hydrochloride (Clenbuterol). Crystal structures of the binuclear and mononuclear Cu(II) complexes with Clenbuterol

摘要

Two new copper(II) complexes with the bronchodilator Clenbuterol (HL) have been synthesized: the binuclear complex CU(2)L(2)Cl(2)(.)4DMSO (1) and the mononuclear CuL(2)(.)2CH(3)OH (2) and have been studied using electronic, IR and EPR spectra, magnetochemical, thermogravinietric and single-crystal X-ray diffraction methods. Each of the Cu(II) centres in the binuclear complex 1 is four coordinated by one terminal chlorine and one nitrogen atom, and by two bridging oxygen atoms from two different ligand molecules. Each molecule of the binuclear complex also links four DMSO molecules by hydrogen bonds of the types S=(OH2N)-H-... and S=(OHN)-H-.... The overall structure is built by sheets of Cu2L2Cl2, parallel to the ab plane, separated by layers of DMSO. In the mononuclear moiety 2, CU(II) is coordinated bidentately with the N and O atoms of two Clenbuterol ligands, forming a nearly square-planar complex CuL2. Two CH3OH molecules are also incorporated in the unit cell, forming hydrogen bonds between the hydroxyl hydrogen atom of CH3OH and the oxygen atoms of the ligands, (CH3OHO)-O-...(1). Both structures correlate well with the spectral, magnetochernical and thermal behaviour of complexes 1 and 2. (c) 2005 Elsevier Ltd. All rights reserved.