Synthesis, characterization and in vitro antitumor activity of some arylantimony ferrocenylcarboxylate derivatives and the crystal structures of [C5H5FeC5H4C(CH3)=CHCOO](2)Sb(C6H4F-4)(3) and [4-(C5H5FeC5H4)C6H4COO](2)Sb(C6H4F-4)(3)

摘要

A series of novel arylantimony ferrocenylcarboxylate derivatives with the formulae [C5H5FeC5H4C(CH3)=CHCOO](2)SbAr3 and [4-(C5H5FeC5H4)C6H4COO](2)SbAr3 (Ar=C6H5, 4-CH3C6H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR and H-1 NMR. The crystal structures of [C5H5FeC5H4C(CH3)=CHCOO](2)Sb(C6H4F-4)(3) and [4-(C5H5FeC5H4)C6H4COO](2)Sb(C6H4F-4)(3) were determined by X-ray diffraction. The two sets of crystal X-ray data show that the antimony atom of the former has a special six-coordinate geometry while that of the latter has a general five-coordinate geometry. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that [C5H5FeC5H4C(CH3)=CHCO2](2)Sb(C6H4Cl-4)(3) and [C5H5FeC5H4C(CH3)=CHCO2](2)Sb(C6H4F-4)(3) at 5 muM show relatively good in vitro antitumor activities. (C) 2003 Elsevier Ltd. All rights reserved.