PLATINUM(II) SUBSTITUTED PYRROLIDINE COMPLEXES - CRYSTAL STRUCTURE OF DICHLORIDE 1,2 DIETHYL 3 AMINOPYRROLIDINE PT-II - REACTIONS WITH DNA AND DINUCLEOTIDES

摘要

The effect of five derivatives of Pt-II, cis dichloro-(1,2-dimethyl-3-aminopyrrolidine)platinum(II), cis dichloro-(l-methyl, 2-ethyl-3-aminopyrrblidine)platinum (II), cis dichloro-(l-ethyl, 2-methyl-3-aminopyrrolidine)platinum(II) , cis dichloro-(1,2-diethyl-3-aminopyrrolidine)platinum(II), and cis dichloro-(1 propyl, 2 methyl-3 aminopyrrolidine) platinum(II) on platination of DNA was studied by CD and melting temperature determination. Reactions with the nucleotides d(ApG) and d(ApA) were also followed by 'H NMR and CD, indicating binding via N(7) and formation mainly of bifunctional, in the case of d(ApG), or monofunctional adducts, in the case of d(ApA). The crystal structure of cis dichloro-(1 ethyl, 2 methyl-3 aminopyrrolidine)platinum (II) shows the analogues cisplatin structure of these active antitumour complexes. This compound is racemic. (C) 1997 Elsevier Science Ltd. [References: 17]