Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N′-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl_2]·4H_2O and uns-cis-[Pt(S,S-eddp)Br_2]

摘要

The syntheses of two novel platinum(IV) complexes of formula [PtX_2(S,S-eddp)]·nH_2O (S,S-eddp = ethylenediamine-N,N′-di-S,S-2-propanoate ion, X = chlorido (1) or bromido (2), n = 4, 0) are reported. The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine-N,N′-di-S,S-2-propanoic acid (H_2-S,S-eddp). The complexes were characterized by elemental analysis, infrared, ~1H and ~(13)C NMR spectroscopy. The spectroscopically predicted geometrical configurations of the obtained complexes were confirmed by X-ray analyses of the crystal structures of the s-cis-[Pt(S,S-eddp)Cl_2]·4H_2O and uns-cis-[Pt(S,S-eddp)Br_2]. These complexes displayed significantly lower in vitro cytotoxicity in comparison to cisplatin.