Outbreak of poliomyelitis in Hispaniola Associated with Circulating type 1 Circulating Type 1 Vaccine-Derived Poliovirus

摘要

An outbreak of paralytic polliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incom- pletely vaccinated children, and cases occurred in communities with very low (7 to 40/100) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating form a single OPV dose given in 1998-1999. The vaccine- derived poliovirus associated with the outbreak had biological properties in- distinguishable form those of wild poliovirus.