The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils

摘要

Neutrophils have a short lifespan that is extended after exposure to granulocyte macrophage colony stimulating factor (GM-CSF) or lipopolysaccharide (LPS)1 . While the survival is regulated by BCL-2 family proteins2 , it is not known which pro-survival proteins are involved. GM-CSF stimulation in neutrophils upregulates A1, but A1-defi- cient mice showed no defects in this cell type3 . MCL-1 is critical for the survival of quiescent neutrophils4,5 , but it is not known whether the same holds true after activation. We hypothesized that A1 and MCL-1 have overlapping roles in the survival of activated neutrophils.