Sensitivity and Kinetics of an NS1-Based Zika Virus Enzyme-Linked Immunosorbent Assay in Zika Virus-Infected Travelers from Israel, the Czech Republic, Italy, Belgium, Germany, and Chile

摘要

Zika virus (ZIKV) is a Mosquito-borne flavivirus that has spread in the last year to 50 countries and territories throughout the Americas (1). Laboratory diagnosis of ZIKV infection is based on detection of Zika RNA in body fluids, such as serum, urine, saliva, and whole blood, or detection of IgM and IgG antibodies against ZIKV in serum. However, Zika diagnosis is challenging due to high cross-reactivity of Zika with other flavivirus antibodies and the limited time that ZIKV RNA is detected in body fluids (2–5).