Serologic Testing for Zika Virus: Comparison of Three Zika Virus IgM-Screening Enzyme-Linked Immunosorbent Assays and Initial Laboratory Experiences

摘要

Zika virus (ZIKV) emerged from obscurity in early 2015 following its detection in Bahia, Brazil (1). Over the next year, ZIKV spread rapidly throughout Latin America, the Caribbean, and into the southern United States, resulting in a major and still ongoing international outbreak (2). Currently, over 1 million cases of suspected or confirmed ZIKV infection have been documented in the Americas by the Pan American Health Organization (3). ZIKV, a single-stranded RNA virus and member of the Flavivirus genus, is primarily transmitted through infected Aedes species mosquitoes, which are also primary vectors for dengue (DENV) and chikungunya (CHIKV) viruses, both of which cocirculate in many regions where ZIKV is now considered endemic (4). ZIKV transmission can also occur through sexual contact, vertically, through blood transfusion, and possibly via secondary, nonsexual contact (5–9).