Temperature-sensitive mutations in Drosophila melanogaster: XIII. Temperature-sensitive periods of the lethal and morphological phenotypes of selected combinations of notch-locus mutations☆☆☆

摘要

Temperature-shiftexperimentswereperformedonfiveNotch-locusgenotypeswithtemperature-sensitivephenotypes.Theresultsshowthattemperature-sensitiveperiods(TSPs)forlethalitymayoccuratanydevelopmentalstage:(1)Ng11Ng11;Dp51b7havingashortembryonicTSPforlethality,(2)Ax16172Na?’40havingasecond-instarTSPforlethality,and(3)Na?’103fanowithalong,possiblypolyphasic,TSP,beginningintheembryonicstageandendinginthepupalstage.Ontheotherhand,TSPsforadultmorphologicalphenotypesappeartoberestrictedtothethirdlarvalinstar:(1)Ax16172Na?’40havingthird-instarTSPsforwingveingappingandocellarbristleloss,and(2)Na?’103splhavingthird-instarTSPsforeyefacetdisarray,wingnotching,bristlenumbervariation,andfusionoftarsalsegments.ThesignificanceoftheseresultsisdiscussedintermsoftheroleoftheNotchlocusindevelopment.