Role of grape seed polyphenols in Alzheimer’s disease neuropathology

摘要

Abstract: Alzheimer’s disease (AD) is an age-related neurodegenerative condition -characterized by a progressive decline in cognitive function. AD affects approximately five million people in the US, creating a devastating financial burden on health care costs and an emotional -burden on caregivers. To date, there is no cure for AD, so researchers are continually exploring novel -avenues for the prevention and treatment of this condition. In this article, we present some -findings from our laboratory and those of others on the potential benefits of a grape seed -polyphenolic extract (GSPE) for the prevention and treatment of AD, including its c-hemical composition, bioactivity, bioavailability, safety, and tolerability, and the mechanisms by which it interferes with AD pathogenesis. Findings presented in this review article support the -development of GSPE as a preventative and/or therapeutic agent in AD.