Formulation and Evaluation of Thermoreversible in-situ Nasal Gel of Rizatriptan Benzoate and Caffeine

摘要

Rizatriptan benzoate undergo hepatic first pass metabolism. Aim of present research work is to overcome hepatic first pass metabolism by formulating in-situ nasal gel along with caffeine to get cumulative effect. Formulation was developed to decrease the mucociliary authorization by using thermo-reversible polymer in gel, thus increase the contact time with nasal mucosa and humanizing the absorption of drug. Gels were prepared by cold technique process and evaluate by Appearance, Viscosity, Gelation Temperature, Permeation Studies, Drug Content, Gel strength etc. The gelation temperature of all studied gel formulations were found in range. pH of gel was in the range and drug content was found between 90-98.86%. Gel strength was found in range of 60-120 sec.