Two Single-Nucleotide Polymorphisms inADAM12Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population

摘要

Objectives.To investigate associations of selected single-nucleotide polymorphisms (SNPs) inADAM12gene with radiographic knee osteoarthritis (rKOA) in Estonian population.Methods.The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs inADAM12gene were genotyped in 438 subjects (303 women) from population-based cohort, aged 32 to 57 (mean 45.4). The rKOA features were evaluated in the tibiofemoral joint (TFJ) and patellofemoral joint.Results.The early rKOA was found in 51.4% of investigated subjects (72% women) and 12.3% of participants (63% women) had advanced stage of diseases. The A allele of synonymous SNP rs1044122 was associated with early rKOA in TFJ, predominantly with the presence of osteophytes in females (OR 1.57; 95% CI 1.08–2.29,P=0.018). The C allele of intron polymorphism rs1871054 carried risk for advanced rKOA, mostly to osteophyte formation in TFJ in males (OR 3.03; 95% CI 1.11–7.53,P=0.018). Also the CCAA haplotype ofADAM12was associated with osteophytosis, again mostly in TFJ in males (P=0.014). For rs3740199 and rs1278279, no statistically significant associations were observed.Conclusion.  ADAM12gene variants are related to rKOA risk during the early and late stages of diseases. The genetic risk seems to be predominantly associated with the appearance of osteophytes—a marker of bone remodelling and neochondrogenesis.