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Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines

机译：TP53和抗衰老DDR1受体对前列腺癌细胞系Raf / MEK / ERK和PI3K / Akt表达及化疗药物敏感性控制的影响

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Background: TP53 plays critical roles in sensitivity to chemotherapy, and aging. Collagen is very important in aging. The molecular structure and biochemical properties of collagen changes during aging. The discoidin domain receptor (DDR1) is regulated in part by collagen. Elucidating the links between TP53 and DDR1 in chemosensitivity and aging could improve therapies against cancer and aging.

机译：背景：TP53在对化学疗法的敏感性和衰老中起关键作用。胶原蛋白对于衰老非常重要。胶原蛋白的分子结构和生化特性在老化过程中发生变化。盘状结构域受体（DDR1）部分受胶原蛋白调节。阐明TP53和DDR1在化学敏感性和衰老之间的联系可以改善针对癌症和衰老的疗法。

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期刊名称 Aging (Albany NY)
作者
William H. Chappell; Saverio Candido; Stephen L. Abrams; Shaw M. Akula; Linda S. Steelman; Alberto M. Martelli; Stefano Ratti; Lucio Cocco; Melchiorre Cervello; Giuseppe Montalto; Ferdinando Nicoletti; Massimo Libra; James A. McCubrey;
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作者单位

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年(卷),期 2020(12),11
年度 2020
页码 -1
总页数 17
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词
TP53; DDR; rapamycin; RAF/MEK/ERK; collagen;

机译：TP53;DDR;雷帕霉素;RAF / MEK / ERK;胶原;

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专利

1. NSK-01105 inhibits proliferation and induces apoptosis of prostate cancer cells by blocking the Raf/MEK/ERK and PI3K/Akt/mTOR signal pathways [J] . Yu Pengfei, Ye Liang, Wang Hongbo, Tumour biology : . 2015,第3期

机译：NSK-01105通过阻断Raf / MEK / ERK和PI3K / Akt / mTOR信号通路抑制增殖并诱导前列腺癌细胞凋亡
2. β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways [J] . Pengyu Su, Bashir Ahmad, Kun Zou, OncoTargets and therapy . 2020,第2期

机译：β-榄乙烯通过PI3K / AKT，RAF-MEK-ERK和NF-κB信号传导途径增强了5-氟尿嘧啶的化学治疗效果
3. RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mT0RC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma [J] . Shaw M. Akula, Stephen L Abrams, Linda S. Steelman, Expert opinion on therapeutic targets . 2019,第7a12期

机译：RAS / RAF / MEK / ERK，PI3K / PTEN / AKT / MT0RC1和TP53路径和监管MIR作为肝细胞癌的治疗靶标
4. Role of the Androgen Receptor and PI3K/Akt in the Survival of Androgen-Refractory Prostate Cancer Cells [C] . Haojie Huang, Donald J. Tindal International Symposium on Hormonal Carcinogenesis . 2005

机译：雄激素受体和PI3K / AKT在雄激素难治性前列腺癌细胞存活中的作用
5. Targeting the MEK5, MEK1/2, and/or Pi3k Pathways Reverses Epithelial to Mesenchymal Transition and Enhances Chemotherapeutic Sensitivity in Breast and Brain Cancers with a Mesenchymal Phenotype [D] . Bhatt, Akshita B. 2021

机译：靶向MEK5，MEK1 / 2和/或PI3K途径将上皮细胞转型的上皮性反转，并通过间充质表型提高乳腺癌和脑癌中的化疗敏感性
6. Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging [O] . Linda S. Steelman, William H. Chappell, Stephen L. Abrams, 2011

机译：Raf / MEK / ERK和PI3K / PTEN / Akt / mTOR通路在控制生长和对癌症和衰老的治疗影响的敏感性中的作用
7. Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines [O] . William H. Chappell, Saverio Candido, Stephen L. Abrams, 2020

机译：TP53和抗衰老DDR1受体对旱獭/ ERK和PI3K / AKT表达和化学治疗药物敏感性的影响及抗衰老DDR1受体在前列腺癌细胞系中的表达及化疗药物敏感性
8. Modulation of Epidermal Growth Factor Receptor Expression by Chemotherapeutic Agents in Breast Cancer Cell Lines [R] . Welch, J. N. 2002

机译：化学治疗剂对乳腺癌细胞系中表皮生长因子受体表达的调节作用

Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines

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