Metabolite and Transcriptomic Differences of 2′-Fucosyllactose 3-Fucosyllactose and Difucosyllactose Assimilation by Bifidobacterium infantis Bi-26 and ATCC15697

摘要

The third most abundant solid in human milk is made up of unique, non-digestible, human milk oligosaccharides (HMOs) that provide an array of health benefits to the infant. They reach the colon intact and are fermented by the infant gut microbiota. HMOs can function as prebiotics for beneficial bacteria helping to shape the intestinal microbiota of breast-fed infants. Many infant formulas contain 2’Fucosyllactose (2’FL) to better mimic the health benefits observed from breast milk. However, research is needed to understand the mechanisms of recognition, uptake, and breakdown of individual monosaccharide moieties by bacteria. Research is also needed to determine if strains within the same species respond similarly to HMOs.