Comparison of Bayesian and frequentist group-sequential clinical trial designs

摘要

An increasing desire for efficiency in clinical trials has led to growing interest in adaptive designs. Frequentist group-sequential designs enable interim analyses to be performed during the conduct of a clinical trial without inflation of the overall type I error rate [ ]. With an increased application of Bayesian methods in clinical trials, a number of researchers have proposed Bayesian group sequential methods [ , ].