Objective To explore the cognitive characters and clinical value of auditory P300 potentials in children with motor development disorder. Methods Thirty children with motor development disorder (observed group) and 30 health subjects (control group) were enrolled, P300 test was performed by the 32-channel event related potential neuroscan, the latency, amplitude, waveform and topography were analyzed. Results Compared to the control group, the latencies of P300 were significantly longer, the amplitudes were significantly lower, the incidences of abnormal waveform and topography were significantly higher in part brain area( P ＜ 0.05, 0.01 ). Conclusions There are typically cognition characteristic of auditory P300 in children with motor development disorder, P300 test can be taken as a reference index in physiologic, pathologic and curative effect observation for the motor development clinically.%目的 探讨运动发育异常儿童听觉认知电位P300特征及其临床应用价值.方法 选择30例运动发育异常儿童(观察组)及30例健康儿童(对照组),采用32导事件相关电位仪进行P300潜伏期、波幅、波形及地形图分布分析.结果 与对照组比较,观察组不同脑部分区P300潜伏期延长、波幅降低、波形及地形图分布异常发生率高(P＜0.05、0.01).结论 运动发育异常儿童听觉认知电位P300特征存在典型变化,临床可将其作为此类儿童运动发育生理病理及疗效观察的参考指标.
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