目的 探讨血清生长素(Ghrelin)与多囊卵巢综合征(PCOS)的关系.方法 选择PCOS患者35例(P-COS组)及正常体检者33例(对照组),两组服75 g葡萄糖粉后,分别检测空腹与服糖1、2h血脂,基础血激素(雌激素、孕激素、卵泡刺激素、黄体生成素、泌乳素、睾酮、雄烯二酮)及Ghrelin水平,计算BMI、腰臀比(WHR)、胰岛素抵抗指数及敏感指数.结果 PCOS组BMI、TG、HDL、胰岛素抵抗指数、空腹胰岛素、Ghrelin、睾酮及雄烯二酮在空腹与服糖1、2h均低于对照组(P＜0.05或＜0.01).相关分析显示,血清Ghrelin与BMI、WHR、雄激素、雄烯二酮、空腹血糖呈负相关(r分别为-0.504、-0.336、-0.440、-0.432、- 0.414,P均＜0.05),与HDL呈正相关(r=0.357,P＜0.05).结论 血清Ghrelin可能在PCOS的病理生理过程中发挥作用.%Objectives To study the relationship between serum ghrelin and polycystic ovary syndrom ( PCOS). Methods 35 patients diagnosed PCOS were recruited, 33 women were voluntary selected as non-PCOS group at the same time. After oral glucose tolerance test (OGTT), insulin serum lipid, based serum hormones of patients were measured. The body mass index (BMI) , waist-hip ratio (WHR) , insulin resistance index (IR) and insulin sensitivity index (ISI) were caculated. Results The serum ghrelin levers, BMI, FINS, 1 hour and 2 hours insulin results, testosterone and an-drostendione, triglyceride and high-density lipoprotein and insulin resistant index in PCOS group were significantly decreased, compaired with normal group (P <0. 05 or <0. 01). The serum ghrelin levers was negatively correlated with BMI, WHR, testosterone, androstendione and FPG (r= -0.504, -0.336, -0.440, -0.432, -0.414, all P<0.05), and positively correlated with HDL (r ≈0. 357, P <0.05). Conclusions Ghrelin could play a role in pathophysiology of PCOS.
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