婴儿维生素A营养状况与麻疹疫苗免疫效果的关系

摘要

目的 探讨婴儿维生素A营养状况及其与麻疹IgG抗体浓度的关系.方法 采取对婴儿照料者进行24h膳食回顾调查和2日膳食记录相结合的方法,了解入选婴儿连续72 h进食的食物及数量.采用NCCW软件计算每人每日维生素A的平均摄入量,高效液相色谱法测定血清维生素A浓度,ELISA法测定麻疹特异性IgG抗体.结果 入选婴儿仅19.7％维生素A摄入量达到推荐摄入量的80％;维生素A营养不良发生率为67.2％;亚临床维生素A缺乏(SVAD)、可疑SVAD及正常对照者之间麻疹IgG抗体平均几何均数滴度倒数(GMRT)对数值有统计学差异(F=33.77,P=0.000),血清维生素A浓度与麻疹IgG抗体GMRT存在正相关(r=0.560,P=0.000).结论 血清维生素A可能与麻疹IgG抗体有效保护水平的维持有一定关系.%Objective To explore the relationship between the status of vitamin A and the level of measles IgG in infants. Methods The recruited infants' feeding information of successive 72 hours was collected through the 24-hour dietary recall method and diet records method. The nutrients intakes were analyzed with a NCCW software for calculation. The concent of serum vitamin A was analyzed by HPLC. ELISA was used to detect themeasles-specific IgG. Results There was only 19. 7% of children whose average daily intake of vitamin A reached the 80% of recommended nutrient intakes (RNI). The incidence rate of vitamin A malnutrition was 67. 2%. There were significant differences (F=33.77P=0.000) from measles IgG LgGMRT among Sub-clinical vitamin A deficiency(SVAD) group, suspicious SVAD group and normal group. The correlation coefficient between the level of serum vitamin A and measles IgG LgGMRT was 0. 560(P = 0.000 ) . Conclusion The results show that the level of serum vitamin A may have influence on the maintenance of an effective IgG level against measles virus.