血清抗CCP抗体、抗MCV抗体与RF联合检测诊断类风湿关节炎的临床价值

摘要

目的 探讨抗环瓜氨酸肽(CCP)抗体、抗突变型瓜氨酸波形蛋白(MCV)抗体和类风湿因子(RF)联合检测诊断类风湿关节炎(RA)的价值.方法 采用ELISA法检测101例RA患者(RA组)、55例非RA自身免疫性疾病患者(非RA组)和55例健康查体者(对照组)血清抗CCP抗体、抗MCV抗体和RF诊断RA水平,并进行比较.结果 RA组抗CCP抗体、抗MCV抗体和RF阳性率均显著高于非RA组和对照组(P均＜0.01).RA组抗CCP抗体、抗MCV抗体和RF的敏感性分别为83.2％、70.3％和79.2％,特异性分别为93.6％、94.5％和75.4％.三项指标联合检测诊断RA的特异性达99.1％,敏感性降至67.3％.结论 抗CCP抗体、抗MCV抗体和RF联合检测可提高诊断RA的准确性.%Objective To investigate the clinical value of combined detection of anti-cyclic citrullinated peptide (antiCCP) antibodies,anti-mutated citrullinated vimentin (anti-MCV) antibodies and rheumatoid factor (RF) in rheumatoid arthritis (RA) diagnosis.Methods Anti-CCP,anti-MCV antibodies and RF were detected by ELISA in 101 RA patients(RA group),55 patients with other rheumatic diseases (non-RA group),and 55 healthy controls (control group).The differences of anti-CCP,anti-MCV antibodies and RF in the three groups were compared.Results The positive ratios of anti-CCP,anti-MCV antibodies and RF were significantly higher in the RA group than those in the non-RA group and control group (P ＜ 0.01).In the RA group,the sensitivity of anti-CCP antibodies was 83.2％ with 93.6％ specificity,the sensitivity of anti-MCV antibodies was 70.3％ and the specificity was 94.5％,the sensitivity of RF was 79.2％ with 75.4％ specificity.The specificity of combined detection of anti-CCP,anti-MCV antibodies and RF was increased to 99.1％,with a lower 67.3％ sensitivity.Conclusions The combined detection of anti-CCP,anti-MCV antibodies and RF could improve the diagnostic accuracy of rheumatoid arthritis (RA).