男性隐性梅毒患者体外受精——胚胎移植治疗的结局分析

摘要

目的 分析男性隐性梅毒患者体外受精—胚胎移植(IVF-ET)治疗的结局,为其行IVF-ET治疗知情选择提供帮助.方法 选择因女方输卵管因素不孕行IVF-ET治疗的患者45对,其中男方隐性梅毒15对(观察组),男方无梅毒感染30对(对照组),两组均行IVF-ET治疗,比较其受精率、卵裂率、优质胚胎率、临床妊娠率及胚胎种植率.结果 观察组受精率54.50％、卵裂率80.00％、优质胚胎率52.60％,明显低于对照组的83.43％、98.86％、75.60％(P均＜0.05),临床妊娠率(18.18％)及胚胎种植率(8.33％)分别低于对照组的46.67％、22.22％,但无统计学差异(P均＞0.05).结论 男性隐性梅毒患者行IVF-ET治疗时受精率降低,受精后形成胚胎、胚胎继续发育能力及种植潜能较低,故其行IVF-ET治疗前应充分知情同意.%Objective To analyze the effect of latent syphilis infection in men on the outcomes of in vitro fertilizationembryo transfer (IVF-ET) and thereby provide more information that will enable patients to make informed choices about IVF-ET.Methods We recruited 45 age-matched couples with tubal infertility.IVF-ET outcomes including the rates of fertilization,cleavage,good quality embryo,clinical pregnancy and implantation in the observation group of 15 men with latent syphilis were compared with those in the control group of 30 age-matched men without syphilis.Results The rates of fertilization (54.50％),cleavage (80.00％) and good quality embryo (52.60％) were significantly lower in the observation group than those in the control group (83.43％,98.86％ and 75.60％,respectively) (all P ＜0.05).The rates of clinical pregnancy (18.18％) and implantation (8.33％) were insignificantly lower in the observation group than those in the control group (46.67％ and 22.22％,respectively) (both P ＞0.05),but the differences were not statistically significant (both P ＞ 0.05).Conclusions Men with latent syphilis have lower fertilization rate,lower potential ability of embryo development and implantation in IVF-ET than men without syphilis.Detailed information should be provided to patients with latent syphilis so that they can make informed choices about IVF-ET.