METHOD FOR PREDICTION OF HYPERCOAGULABLE COMPLICATIONS OF GESTATION AFTER TRANSFER OF 'FRESH' EMBRYOS IN IVF PROGRAMS

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to obstetrics and gynecology, and can be used for prediction of hypercoagulable complications of gestation after transfer of "fresh" embryos in IVF programs. Method consists in determining values of parameters of clotting test (APTT) and thromboelastography (ANGLE, K), as well as polymorphism of gene associated with risk of endothelial dysfunction (VEGF-A: -2578CA), with subsequent calculation of prognostic index H by formula: H=VEGF-A2578CC*K1+APTT*K2+K*K3+ANGLE*K4+const, where: H – prognostic index of hypercoagulable complications of gestation, VEGF-A 2578CC – if there is – 1, if not – 0, APTT – level of activated partial thromboplastin time in woman's blood, c, K – time of formation of clot according to TEG, min, ANGLE is fibrin network growth rate according to TEG data, deg, K1, K2, K3, K4, K5 – coefficients (K1 = -0.53, K2 = -1.03, K3 = -18.23, K4 = 1.00), 4.65 – const. If H≥1, high risk of hypercoagulable complications of gestation in pregnancy is predicted after transfer of "fresh" embryos in IVF programs. If H1, low risk of hypercoagulable complications of gestation in pregnancy is predicted after transfer of "fresh" embryos in IVF programs.;EFFECT: use of the given method enables to isolate a high-risk group on the formation of hypercoagulable complications of gestation in pregnancy after the transfer of "fresh" embryos in the IVF programs and to conduct a timely therapy of the given pathology in the given patients.;1 cl, 3 ex