变应性鼻支气管炎患者PAF-AH基因型与血浆PAF-AH活性的关系

摘要

目的 探讨血小板活化因子—乙酰水解酶(PAF-AH)基因型与变应性鼻支气管炎(ARB)患者血浆PAF-AH活性的相关性.方法 根据PAF-AH基因型的不同,将ARB患者及健康对照者分别分为GG型、GT型和TT型,对其3种基因型的血浆PAF-AH活性进行统计分析.结果 在ARB患者及健康对照组中,不同基因型血浆PAF-AH活性差异有统计学意义(P均＜0.05).GG型血浆PAF-AH活性显著高于GT型及TT型,GT型血浆PAF-AH活性显著高于TT型,两两之间差异均具有统计学意义(P均＜0.05).结论 ARB患者PAF-AH不同基因型对血浆PAF-AH活性可能有明显影响.%Objective To investigate the relationship between the plasmatic PAF-AH genotypes and the activity of PAF-AH in allergic rhinobronchitis.Methods According to the plasmatic PAF-AH genotypes,the patients with allergic rhinobronchitis and healthy controls were divided into three groups (GG group,GT group,TT group).The activity of plasmatic PAF-AH was measured in the patients with allergic rhinobronchitis and healthy controls with different genotypes.Results Significant statistical difference of plasmatic PAF-AH activity exited among the three different genotype groups both in patients and control groups(all P ＜ 0.05).The activity of plasmatic PAF-AH in genotype GG group was higher than that in genotype GT and TT,still genotype GT higher than TT.There were statistical differences between any two groups(all P ＜ 0.05).Conclusion The genotypes of the plasmatic PAF-AH may influence PAF-AH activity.