SDF-1、CXCR4在三阴性乳腺癌组织中的表达及其与患者预后的相关性

摘要

目的：探讨基质细胞衍生因子-1（SDF-1）及基质细胞衍生因子受体-4（CXCR4）在三阴性乳腺癌（TNBC）组织中的表达和临床意义。方法用免疫组化法检测77例TNBC组织中SDF-1和CXCR4的表达，分析SDF-1和CXCR4与TNBC临床病理特征及患者预后的关系。结果 SDF-1和CXCR4在TNBC中高表达率分别为41．6％、64．9％，且二者表达呈显著正相关（P＝0．041）；SDF-1和CXCR4高表达与患者年龄、肿瘤大小、临床分期及组织学分级不相关（P＞0．05），与淋巴结转移及无瘤生存呈显著正相关；多因素分析结果表明：SDF-1是TNBC患者无瘤生存的独立预后因素（ OR＝2．318，95％CI＝1．028～5．230）。生存分析显示SDF-1和CXCR4高表达者无瘤生存时间短于低表达者（P均＜0．05）。结论 TNBC中SDF-1／CXCR4表达可作为判断TNBC预后的重要生物学指标。%Objective To investigate the expression and clinical significance of stromal cell derived factor-1 ( SDF-1) and its receptor stromal cell derived factor receptor-4 ( CXCR4) in triple negative breast cancer( TNBC) tissue.Methods The expression of SDF-1 and CXCR4 of 77 TNBC cases were detected by using immunohistochemistry.The correlation between SDF-1/CXCR and clinical pathological features and prognosis were assessed.Results The expression rate of SDF-1 and CXCR4 in TNBC tissues was 41.6%, 64.9%, respectively.The expression rate of SDF-1 and CXCR4 in TN-BC tissues were significantly correlated (P=0.041).The high expression of SDF-1 and CXCR4 were not correlated with age, tumor size, clinical stage and histological grade(P>0.05), but obviously correlated with lymph node metastasis(PS-DF-1=0.021,PCXCR4=0.010) and disease free survival(PSDF-1=0.023,PCXCR4=0.015).COX regression multi-variate analysis showed that SDF-1 was an independent prognostic factor of disease free survival in TNBC(OR=2.318, 95%CI=1.028-5.230).Kaplan-Meier survival analysis indicated that time of disease free survival was shorter in SDF-1 and CXCR4 high expression patients than that in low expression patients(PSDF-1=0.011,PCXCR4=0.018).Conclu-sions The expression of SDF-1 and CXCR4 in TNBC tissues can be used as important biomarkers of the prognosis.