盐酸羟考酮控释片联合普瑞巴林治疗带状疱疹后神经痛的临床应用

摘要

Objective To investigate the efficacy and safety of controlled-release oxycodone combined with pregabalin in the treatment of postherpetic neuralgia.Methods Fifty-two patients with postherpetic neuralgia were randomly divided into group A and group B ,26 cases in each group.Patients of group A receivedsimple controlled-release oxycodone, while patients of group B received oxycodone combined with pregabalin, then the intensity of pain, mean daily oxycodone doses, quality of life, adverse effect of two groups were observed.Results The combination of oxycodone plus pregabalin and oxycodone monotherapy were both effective for alleviating postherpetic neuralgia, and the combination of oxycodone plus pregabalin was more effective than simple controlled-release oxycodone to controll postherpetic neuralgia from 14 d to 28 d.Patients in group B used lower oxycodone doses, combination therapy was also beneficial for QoL and SF-36 parameters, namely combined therapy consistently achieved lower scores than monotherapy ,all patients had a better safety profile ,except for the slightly high incidence of dizziness ,dry mouth and somnolence in combination therapy.Conclusion The combination of controlled-release oxycodone plus pregabalin is effective and safe for the management of postherpetic neuralgia.%目的 探讨盐酸羟考酮控释片联合普瑞巴林治疗带状疱疹后神经痛的疗效和安全性.方法 将52例带状疱疹后神经痛患者随机分成2组,每组26例.A组使用盐酸羟考酮控释片治疗,B组联合使用普瑞巴林,观察比较两组疼痛缓解程度、用药量、生活质量及不良反应情况.结果 两组患者疼痛均明显缓解,B组患者14～28 d的疼痛缓解率明显优于A组,盐酸羟考酮控释片使用量低;B组患者的生活质量及SF-36评分优于A组;B组患者除了头晕、口干及嗜睡发生率略高之外,其他不良反应与A组比较差异无统计学意义.结论 盐酸羟考酮控释片联合普瑞巴林治疗中重度带状疱疹后神经痛疗效确切,安全可行.