目的 观察小剂量沙利度胺治疗白塞病的临床疗效.方法 收集2005年9月起,在我院门诊及住院的符合白塞病诊断标准的患者38例,随机分为低剂量组和高剂量组.高剂量组19例,给予沙利度胺,100 mg/次,每晚1次,并给予对症治疗;低剂量组19例,均给予沙利度胺 50 mg/次,每晚1次,正清风痛宁缓释片120 mg/次,2次/d.疗程半年.治疗前后主要观察指标包括临床症状的发生频率和程度等,次要观察指标包括血沉、C反应蛋白,以及用药安全情况等.结果 低剂量组除1例出现不良反应未坚持治疗外,余18例患者治疗半年后,多个主要观察指标中均有不同程度的改进,且疗效优于高剂量组,总有效率94.4%,但两组差异无统计学意义(P>0.05),且复发减少.常见的不良反应为困倦、头晕、口干和便秘.结论 在正清风痛宁缓释片配合治疗下,小剂量沙利度胺治疗白塞病患者,效果显著,毒副作用小.%Objective To investigate the effect of low dose thalidomide combined with Chinese medicine for treating patients with Bechet's disease. Methods 38 patients with Bechet's disease were divided into two groups according to resourceful principle,group A( 19 cases)was given thalidomide( 100 mg/d)and expectant treatment;group B (19 cases)was given thalidomide( 50 rog/d)and Zhengqing fengtongning (120 mg, twice a day). The course of treatment was half a year. Results After treating for a course,all the patients' indexes have improved,the total effective rate of treatment group was 94. 4％ with slight side effects. Conclusion Low dose thalidomide combined with Zhengqing fengtongning has a significant effect on treating Bechet's disease with slight side effects.
展开▼
