Objective To investigate the clinical effect of weisu granule combined with esomeprazole magnesium enteric - coated tablets on gastric mucosal damage after PCI and its impact on antiplatelet effect of clopidogrel. Methods A total of postoperative inpatients with gastric mucosal damage of PCI were selected in the People's Hospital of Yanggu County from March 2013 to January 2015,and they were randomly divided into control group and experiment group,each of 60 cases. All of the patients received clopidogrel and aspirin after treatment,and patients of control group received extra esomeprazole magnesium enteric - coated tablets,while patients of experiment group received extra weisu granule combined with esomeprazole magnesium enteric - coated tablets,both groups treated for 4 weeks. Clinical symptoms severity score(including stomachache,abdominal distension,acid reflux,stomach burning and belching),inflammatory status of inflammatory status( infiltrating degree of monocyte and neutrophil)and platelet reactivity index were compared between the two groups before and after treatment. Results No statistically significant differences of stomachache severity score,abdominal distension severity score,acid reflux severity score,stomach burning severity score or belching severity score was found between the two groups before treatment,nor was acid reflux severity score or stomach burning severity score between the two groups after treatment(P ﹥ 0. 05),while stomachache severity score,abdominal distension severity score and belching severity score of experiment group were statistically significantly lower than those of control group after treatment(P ﹤ 0. 05). Stomachache severity score,acid reflux severity score and stomach burning severity score of the two groups after treatment were statistically significantly lower than those before treatment,abdominal distension severity score and belching severity score of experiment group after treatment were statistically significantly lower than those before treatment(P ﹤ 0. 05),while no statistically significant differences of abdominal distension severity score or belching severity score of control group was found before treatment and after treatment(P ﹥ 0. 05). No statistically significant differences of infiltrating degree of monocyte or neutrophil was found between the two groups before treatment( u = 0. 441,0. 078,P =0. 802,0. 962),while infiltrating degree of monocyte and neutrophil of experiment group were statistically significantly milder than those of control group( u = 9. 554,16. 617,P = 0. 009,0. 000). No statistically significant differences of platelet reactivity index was found between the two groups before treatment or after treatment(P ﹥ 0. 05). Conclusion Weisu granule combined with esomeprazole magnesium enteric - coated tablets can effectively relieve the clinical symptoms and repair the gastric mucosa of patients with gastric mucosal damage after PCI,without affecting the antiplatelet effect of clopidogrel.%目的：探究胃苏颗粒联合埃索美拉唑镁肠溶片治疗经皮冠状动脉介入治疗（PCI）术后胃黏膜损伤的临床疗效及其对氯吡格雷抗血小板作用的影响。方法选取2013年3月—2015年1月在阳谷县人民医院住院治疗的PCI 术后胃黏膜损伤患者120例，随机分为试验组与对照组，每组60例。患者 PCI 术后均常规服用氯吡格雷、阿司匹林治疗；试验组患者在此基础上给予胃苏颗粒联合埃索美拉唑镁肠溶片治疗，对照组患者在此基础上给予单纯埃索美拉唑镁肠溶片治疗；两组患者均治疗4周。比较两组患者治疗前后临床症状（腹痛、腹胀、反酸、胃灼热、嗳气）严重程度评分、胃黏膜组织学炎症程度（单核细胞和中性粒细胞浸润程度）、血小板反应指数。结果治疗前两组患者腹痛、腹胀、反酸、胃灼热、嗳气严重程度评分比较，差异无统计学意义（P ﹥0.05）；治疗后试验组腹痛、腹胀、嗳气严重程度评分均低于对照组（P ﹤0.05）；治疗后两组患者反酸、胃灼热严重程度评分比较，差异无统计学意义（P﹥0.05）。治疗后两组患者腹痛、反酸、胃灼热严重程度评分分别低于治疗前，试验组腹胀、嗳气严重程度评分低于治疗前（P ﹤0.05）；治疗前后对照组患者腹胀、嗳气严重程度评分比较，差异无统计学意义（P ﹥0.05）。治疗前两组患者单核细胞和中性粒细胞浸润程度比较，差异无统计学意义（u 值分别为0.441、0.078，P 值分别为0.802、0.962）；治疗后试验组患者单核细胞和中性粒细胞浸润程度轻于对照组（ u 值分别为9.554、16.617，P 值分别为0.009、0.000）。治疗前后两组患者血小板反应指数比较，差异无统计学意义（P ﹥0.05）。结论针对 PCI 术后采用抗血小板治疗导致的胃黏膜损伤患者，胃苏颗粒联合埃索美拉唑镁肠溶片可有效缓解其临床症状、修复胃黏膜，且不影响氯吡格雷的抗血小板作用。
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