本文研究了当归提取物LIG的抗炎,解热活性.研究发现LIG(2.5,5,10 mg/kg)对角叉菜和右旋糖苷诱导的足肿胀的抑制率分别为22.2%,49.4%,76.5%和20.8%,44.2%,75.3%(P＜0.001);对棉球肉芽肿的抑制率为29.2%,44.9%,58.8%(P＜O.001);对小鼠白细胞迁移的抑制率为20.7%,35.6%,48.2%(P＜0.001).此外,LIG可降低啤酒酵母导致的高热(P＜0.001).并且,LIG的抗炎,解热作用均成剂量依赖性.以上结果显示LIG具有非常强的抗炎,解热活性.%In this study, the anti-inflammatory,analgesic and antipyretic effects of Z-ligustilide (LIG) extracted from Radix angelicae sinensis were investigated. The effects of LIG (2.5,5 and 10 mg/kg, ig) on acute and chronic phases of inflammation were studied in carrageenan- and dextran-induced paw edema and cotton pellet-induced granuloma, respectively. Antipyretic activity of LIG was evaluated in yeast-induced hyperpyrexia model in rats. In the anti-inflammatory studies, LIG showed significant dose-dependent inhibition of 22.2%,49.4% and 76.5% and 20.8%,44.2% and 75.3% in carrageenan-and dextran-induced paw edema,and 29.2% ,44.9% and 58.8% in cotton pellet-induced granuloma, respectively ( P ＜ 0.001 ). LIG also exhibited significant dose-dependent inhibition of peritoneal leukocyte migration in mice at the inhibition rate of 20.7,35.6 and48.2% ( P ＜ 0.001 ). Oral administration of LIG significantly reduced the elevated temperature in rats ( P ＜ 0.001) .The results suggest that LIG possesses potent anti-inflammatory and analgesic activities.
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