百两金皂苷类似物的化学与药理学研究进展

摘要

对百两金皂苷类似物的化学和药理活性进行文献综述.迄今报道的百两金皂苷类似物大约有60个,其齐墩果烷三萜母核上具有多种与生物活性有关的特征取代基,包括13β,28-环醚、30-氧化甲基和3-O-糖链等.该类物质多具抗肿瘤、抗炎和抗真菌等药理活性,值得深入研究.%The triterpenoidal analogues of ardisiacrispin reported in the literatures were summarized. There are about 60 triterpenoidal analogues possessing characteristic substituent groups such as 13β,28-epoxy bridge,30-oxidized methyl, and 3-0-glycan chain which were proved necessary to the pharmacological activity. The analogues of ardisiacrispin presented anti-cancer,anti-inflammatory and anti-fungal activities, and they are worth doing further pharmaceutical researches.