杭白菊保肝作用研究

摘要

本实验对杭白菊的保肝作用进行了研究.以四氯化碳诱导的小鼠急性肝损伤为模型,将杭白菊乙醇提取物和多糖部分分为高、中、低三个剂量组,以联苯双酯为阳性对照,灌胃给药8d,分别测定血清谷丙转氨酶(GPT)、谷草转氨酶(GOT)、肝匀浆丙二醛(MDA)、肝匀浆超氧化物歧化酶(SOD).结果表明:杭白菊乙醇提取物和多糖部分高剂量组对血清GPT、GOT具有显著的抑制作用,杭白菊乙醇提取物高剂量组显著拮抗肝脏MDA的升高.表明杭白菊有保护四氯化碳所致肝损伤的作用.%The protective effect of Dendranthema morifolium on CC14-induced liver injury in mice was studied. The mice were randomly divided into nice groups according to their weight,and bifendate ( DDB) as a positive control. After feeding with D. morifolium for 8 d, the contents of GPT, GOT in serum and the content of MDA, SOD in liver were measured. The results showed that D. morifolium of high doses of serum GPT,GOT has significant inhibitory effect and prevent the rise of MDA in liver. It shows that the D. morifolium has the protection of carbon tetrachloride induced liver injury.