首次利用体外α-葡萄糖苷酶抑制模型对内蒙古产3种蒺藜科植物的9个提取物进行活性评价,并与阳性对照Acarbose比较,发现3种植物均有抑制α-葡萄糖苷酶活性.其中白刺石油醚提取物对α-葡萄糖苷酶的抑制活性(IC50 =81.80 mg/L)最高,其余依次为小果白刺乙酸乙酯提取物(IC50=610.29 mg/L),霸王石油醚(IC50=627.22mg/L)和乙酸乙酯提取物(IC50 =838.40 mg/L),它们的抑制活性远大于阳性对照Acarbose( IC50=1103.01 mg/L).结果发现,不同植物不同溶剂提取物的α-葡萄糖苷酶抑制活性不同.同一植物不同溶剂提取物相比较,甲醇提取物的α-葡萄糖苷酶抑制活性不及乙酸乙酯和石油醚提取物.%The a-glucosidase inhibitory activities of nine extracts from three species of Zygophyllaceae in Neimenggu were evaluated in vitro by 96-microplate-based method for the first time. All these three species showed a-glucosidase inhibitory activities compared with the positive control " acarbose ". Among these nine extracts, petroleum ether extract of Nitraria tangutorum Bobr. Had the highest inhibitory activity (IC50 =81.80 mg/L) .followed by the ethyl acetate extract of N. Sibirica Pall( IC50 = 610.29 mg/L) ,the petroleum ether extract (IC50, = 627. 22 mg/L) and ethyl acetate extract (IC50 =838.40 mg/L) of Sarcozygium xanthoxylon Bunge,all of which are much higher than that of acarbose (IC50= 1103.01 mg/mL). Different extracts of different plants showed different inhibitory activies, while the inhibitory activity of different extracts from the same plant varied a lot. The methanolic extract had lower inhibitory activity than that of ethyl acetate extract and petroleum ether extract.
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