海绵来源真菌天然产物的研究进展

摘要

随着海洋药物及其药物先导化合物研究的不断深入,海绵来源微生物,因其种类繁多、代谢产物复杂多样,引发了科研工作者的兴趣.许多化合结构新颖、具有强烈生物活性的化合物从海绵来源真菌中发现,包括多肽、生物碱、聚酮类、萜类等.本文仅就近几年来所报道的海绵来源真菌新天然产物的结构类型及其生物活性做简要介绍.%Along with the in-depth research of marine drugs and leading compounds,sponge-associated microbes attract the interest of researchers,because of its great varieties and complicated metabolites.A number of bioactive compounds with unique structural features and strong biological activities were isolated from sponge-associated fungi,including peptides,alkaloids,polyketides,terpenoids.This paper reviewed the types of compound structures and their biological activities of new natural products from sponge-derived fungi reported in recent years.