急性冠状动脉综合征患者外周血促红细胞生成素的变化及其临床意义

摘要

Objective To study the level and its clinical significance of peripheral blood erythropoietin ( EPO) in patients with acute coronary syndrome ( ACS). Methods The serum EPO levels were measured by enzyme-linked immunosorbent assay in 68 patients with ACS [35 patients with acute myocardial infarction (AMI) and 33 patients with unstable angina pectoris (UAP) ] ,28 patients with stable angina pectoris (SAP) and 30 controls with normal coronary arteriography. The ACS patients were classified into intracoronary stent implantation group (26 cases) and un-implantation group (42 cases). Results The serum EPO level in ACS group [ (1.21 ±0. 27)mg/L] was significantly higher than that in SAP group [(0.90 +0. 23)mg/L] and that in control group [(0.81 ±0. 36)mg/L] (P<0.01). The serum EPO level in AMI group was higher than those in UAP group and control group (P <0. 05). The serum EPO level in implantation group was higher than that in un-implantation group (P <0. 05). Conclusions The serum EPO level is related with ACS. The serum EPO level will increase in ACS patients with intracoronary stent implantation.%目的 探讨急性冠状动脉综合征(ACS)患者外周血促红细胞生成素(EPO)的水平及临床意义.方法 采用酶联免疫吸附试验检测68例ACS患者[急性心肌梗死(AMI)35例、不稳定型心绞痛(UAP)33例]、28例稳定型心绞痛(SAP)和30名冠状动脉造影正常者(对照组)外周血血清EPO的水平.根据是否行支架植入术将ACS患者分为支架组(26例)和无支架组(42例).结果 ACS组血清EPO水平为(1.21±0.27)mg/L,明显高于SAP组[(0.90 ±0.23) mg/L]和对照组[(0.81±0.36) mg/L](P均＜0.01).AMI组EPO水平显著高于UAP组和对照组(P均＜0.05).ACS支架组EPO水平明显高于非支架组(P＜0.05).结论 EPO水平与ACS密切相关,支架手术可导致外周血EPO水平增高.