血清甲状腺激素水平的检测在乳腺癌患者中的临床意义

摘要

目的:分析乳腺癌患者血清甲状腺激素水平的检测及临床意义.方法:收集恶性乳腺肿瘤患者40例(恶性乳腺肿瘤组)、良性乳腺肿瘤患者46例(良性乳腺肿瘤组)与健康人群46例(对照组),检测血清总三碘甲状腺原氨酸(T3)、游离总三碘甲状腺原氨酸(FT3)、总甲状腺激素(T4)、游离甲状腺素(FT4)、促甲状腺素(TSH)及甲状腺过氧化物酶抗体(TPO-Ab)的水平,并分析其与乳腺癌临床病理因素的关系.结果:恶性乳腺肿瘤组T3水平明显低于对照组与良性乳腺肿瘤组(P ＜0 . 05 ),且与肿瘤大小、临床分期有关(P＜0. 05);恶性乳腺肿瘤组的TPO-Ab阳性表达率明显高于良性乳腺肿瘤组和对照组(P＜0. 05),且与肿瘤大小、TNM分期、ER及PR表达有关(P＜0. 05).结论:乳腺癌患者血清甲状腺激素水平与患者的病情严重程度相关,有助于评估病情和判断预后.%Objective:To analyze the serum thyroid hormone level in patients with breast cancer and its clinical significance. Methods:Forty patients with malignant breast tumor,46 patients with benign breast tumor and 46 healthy people (control group)were enrolled in this study. Detect serum total triiodothyronine (T3),free triiodothyronine (FT3),total thyroid hormone (T4),free thyroxine (FT4),thyrotropin (TSH)and thyroid peroxidase (TPO-Ab) and relationship with clinicopathological factors of breast cancer. Results:The level of T3 in malignant breast tumor group was significantly lower than that in control group and benign breast tumor group (P＜0. 05),and was related to tumor size and clinical stage (P＜0. 05). The positive rate of TPO-Ab in malignant breast tumor group was signifi-cantly higher than benign breast tumor group and the control group (P＜0. 05),and related with tumor size,TNM stage,ER expression,PR expression (P＜0. 05). Conclusion:Serum thyroid hormone level in patients with breast cancer is related to the severity of the patient's condition,which helps to evaluate the condition and prognosis.