Objective: To approach the clinical effect and adverse reaction of recombinant metant human tumor necrossis factor ( rmhTNF ) and DDP in the treatment of malignant pleural effusion. Methods: Sixty patients with maligant pleural effusion were randomly devided into two groups:groupTNF was infused with rmhTNF, the another one was infused with DDP. The effective rate, responding time and adverse reaction were observed. Results: The total effective rate of rmhTNF group was 86.7％ ,while it was 66.7％ in groupDDP. There was a significant difference between two groups ( P ＜ 0.05 ). Conclusion: The rmhTNF is more effective and responds qulickly with less adverse reaction for treatment of maliganat pleural effusion.%目的:探讨注射用重组改构人肿瘤坏死因子(recombinant metant human tumor necrossis factor,rmhTNF)和顺铂(cisplatin,DDP)治疗恶性胸水的疗效和不良反应.方法:将60例恶性胸水患者随机分为rmhTNF组和DDP组,观察各组的疗效、起效时间和副反应.结果:TNF组总有效率86.7%,DDP组总有效率66.7%,TNF组效果好于DDP组,P＜0.05,有统计学意义.结论:使用rmhTNF治疗恶性胸水起效较快,疗效确切,较顺铂治疗副反应小,操作简便,有临床应用价值.
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