Objective : To investigate the expression of E - cadherin ( E - cad ) and VEGF and its relationship with the clinical pathological features in young women with breast carcinoma. Methods : The expressions of E - cadherin and VEGF proteins were detected using immunohistochemistry in breast cancer tissues of 80 young and 80 postmenopausal women with breast cancer for analysing their association with clinical and pathological characteristics. Results : The rates of axillary lymph node metastasis was higher in young women than in postmenopausal women. The expressions rates of E - cad and VEGF were significantly diferent in young and postmenopausal breast cancer tissues ( P ＜ 0. 01 ). Patients with axillary lymph node metastasis had significantly higher positivity rate of VEGF expression than those without( P ＜ 0. 01 ) , but the E - cadherin expression was reverse. VEGF expression was inversely correlated with E - cad expression in young patients ( P ＜ 0. 01 ). Conclusion: Low expression of E - cad and over - expression of VEGF indicate the invasive activity in young women with breast cancer.%目的:探讨上皮钙黏蛋白(E-cadherin,E-cad)和血管内皮生长因子(VEGF)在青年女性乳腺癌组织中的表达及其与病理特征的关系.方法:应用免疫组化方法检测80例青年女性,80例绝经后乳腺癌组织中E-cad和VEGF的表达情况,分析它们之间及其与临床病理指标之间的关系.结果:青年组较绝经组患者淋巴转移率高(P<0.01)；青年组与绝经组患者组织E-cad和血管内皮生长因子的表达差异皆有显著性意义(P<0.01)；各组中腋窝淋巴结转移者和未转移者E-cad和血管内皮生长因子的表达差异均有显著性意义(P<0.01)；青年乳腺癌组织中E-cad和血管内皮生长因子基因表达成负相关(P<0.01).结论:青年乳腺癌侵袭性强,E-cad低表达和血管内皮生长因子基因高表达是预测青年乳腺癌恶性侵袭能力极有价值的生物学指标.
展开▼
