胃癌组织中Survivin和HIF-1α的表达及临床意义

摘要

目的:研究胃癌组织中Survivin和HIF-1α的表达情况,初步分析它们与胃癌生物学行为之间的关系.方法:采用免疫组织化学SP法检测64例胃癌和15例正常胃黏膜组织中Survivin和HIF-1α的表达.结果:64例胃癌组织中Survivin和HIF-1α的阳性表达率分别为75%和65.63%,Survivin与HIF-1α在胃癌组织中的表达水平明显高于正常胃组织中的表达水平(P<0.05).Survivin和HIF-1α的表达与胃癌的临床TNM分期、浸润深度和淋巴结转移有关(P<0.05);与患者的年龄、性别和组织学分级无关.Survivin和HIF-1α之间存在显著相关性(rs=0.328,P<0.05).结论:Survivin和HIF-1α在胃癌的发生发展过程中起着重要的作用,联合检测可为胃癌的早期诊断、治疗和预后判断提供必要的理论依据.%Objective : To study the expression of Survivin and hypoxia inducible factor - lalpha ( HIF - 1α ) in gastric carcinoma. Methods : Survivin and HIF - 1 αexpression were detected by immunohistochemistry in 64 cases of gastric carcinoma and 15 cases of normal gastric mucosa tissues. Results: The positive rates of Survivin and HIF lαin 64 cases of gastric carcinoma were 75％ and 65. 63％ respectively. The expressions of Survivin and HIF lαwere significantly higher in gastric carcinoma than in normal gastric mucosa tissue( P ＜ 0. 05 ). The expressions of Survivin and HIF - lαin gastric carcinoma were significantly associated with TNM stage,inoasive depth and lymph node metastasis ( P ＜ 0. 05 ) but not with patient' s age , sex and tumor grade. There was positive correlation between Survivin expression with HIF - 1α ( rs =0. 328 ,P ＜0. 05 ). Conclusion: Survivin and HIF - 1α may play important roles in oncogenesis and progression of gastric carcinoma. Detection of Survivin and HIF - 1α protein may have potential effects on early diagnosis , treatment and prognosis of gastric carcinoma.