Objective : To investigate the clinicopathological features of alpha - fetoprotein producing gastric carcinoma and reltion with vascular endothelial growth factor.Methods : Two hundred and sixty - two cases of gastric carcinoma were divided into AFP - positive group and AFP - negative group.The expressions of AFP and VECF of all patients sample were examined by immunohistochemical method .Sex , age , tumor site , diameter , gross type , differentiation , liver and lymph node metastasis , TNM stage and prognose were compared between the two groups.Results : The rates of liver metastasis,number of metastasis lymph nodes , stage Ⅳ carcinoma in AFP - positive group were significantly higher than those in AFP - negative group( P ＜0.01) .The positive rate of VEGF in AFP - positive tumors was 90.5％ , significantly higher than that in AFP - negative tumors 67 .2％ ( P ＜ 0.05 ) .1 ,3 ,5year - survival rates in AFP - positive group( 58.7％ ,13.1％ ,5.9％ ) were significantly lower than those in AFP - negative group( 92.1％ ,58.3％ ,32.5％ ) ( P ＜0.05) .Condusion : Alpha - fetoprotein producing gastric carcinoma has significantly higher malignant behavior and poorer prognosis, which may be related to liver and lymph node metastasis.Examining the AFP and VEGF of gastric carcinoma can be regarded as the objectivity prognostic indiciar.%目的:探讨AFPGC生物学特性及其与VEGF的关系.方法: 将262例胃癌患者分成AFP阳性和阴性两组.采用免疫组化方法检测胃癌组织中AFP及VEGF的表达,比较两组患者的性别、年龄及胃癌生长部位、大小、大体类型、分化程度、肝脏转移、淋巴结转移、临床分期以及生存率.结果:AFP阳性组肝脏转移、多个淋巴结转移发生率及临床IV期胃癌比例均明显高于AFP阴性组(P<0.01);AFP阳性组的胃癌组织中VEGF阳性表达率为90.5%,明显高于AFP阴性者的67.2% (P<0.05),AFP阳性组的1、3、5年生存率分别为58.7%、13.1%、5.9%,显著低于AFP阴性组的92.1%、58.3%、32.5%(P<0.05).结论:AFPGC是一种恶性程度高、易发生肝脏和淋巴结转移的预后不良的肿瘤,联合检测AFP和VEGF,可作为判定胃癌侵袭转移能力的一项客观指标.
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