Objective: To evaluate the results of combined chemotherapy with paciitaxei plus Nedaplat in treatment of advanced nonsmall cell lung cancer in elderly. Methods: All 52 patients with advanced non - samll cell lung cancer were treated with paclitaxel plus nedaplat. PTX 1 35mg/m ,2 by intravenous infusion on day 1 , and NDP 60 - 80mg/m ,2 by intravenous infusion on day 1. The treatment was repeated every 21 or 28 day, up to 2 cycles. Results: All 52 patients were evaluable for efficacy . The overall response rate ( RR) was 32. 7 % ( CR; 1, PR: 16) and 36.3% in first treatment. The major toxicities included myelosuppression, and other side effects were mild. Conclusion : Paclitaxel plus nedaplat were effective and well tolerable regimens in the treatment of advanced non — small cell lung cancer in elderly.%目的:观察紫杉醇联合奈达铂治疗老年非小细胞肺癌的疗效和毒副反应.方法:52例老年Ⅲ-Ⅳ期非小细胞肺癌患者,应用紫杉醇135mg/m2,奈达铂60-80mg/m2,静脉滴注,d1,21-28d为1个周期,用药2个周期后评估疗效和毒副反应.结果:CR1例,PR16例,总有效率32.7％,首治患者的有效率为36.3％.主要毒副反应为骨髓抑制,消化道反应及肝肾功能损害轻微.结论:紫杉醇联合奈达铂治疗老年非小细胞肺癌有较好的临床疗效,毒副反应轻,耐受性好.
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