TP与PF方案在宫颈癌新辅助化疗中的对比研究

摘要

目的:对比观察紫杉醇联合顺铂(TP)与氟尿嘧啶联合顺铂(PF)在宫颈癌新辅助化疗中的疗效和毒副作用.方法:66例Ⅰb2-Ⅱb期宫颈癌患者,随机分为两组,A组(32例)行PF方案化疗两周期、B组(34例)行TP方案两周期,比较两组疗效及毒副作用.结果:A、B两组两周期化疗后有效率分别达43.33％和65.63％,完全缓解率分别为6.67％ (2/30)和12.50％(4/32),B组有效率明显高于A组,统计学比较差异有显著性.两组毒副作用相当.结论:紫杉醇联合顺铂是宫颈癌较为理想的新辅助化疗方案.%Objective:To evaluate and compare the efficacy and toxicity of paclitaxel and cisplatin (TP) versus fluorouracil plus cisplatin (PF) in neoadjuvant chemotherapy for cervical cancer. Methods: All 66 patients with stageⅠ b2 ~ Ⅱ b carcinoma of cervix were randomly divided into two groups, group A (32 patients) underwent two cycles of PF chemotherapy, while group B (34 patients) underwent two cycles of TP chemotherapy, and the efficacy and toxic-ity were compared. Results: After two cycles of chemotherapy, the efficiency was significantly higher in group B versus group A(65.63% vs 43. 33% , respectively), complete remission rate (12. 50% vs 6. 67% ) , and there was statistically significant difference. The toxity in two groups was similar. Conclusion: Paclitaxel plus cisplatin is more ideal neoadjuvant chemotherapy for cervical cancer.