SDF-1/CXCR7在肝细胞癌中的表达及临床意义

摘要

Objective:To investigate expressions of chemokine SDF - 1 and its receptor CXCR7 and relationship between their expressions and clinicopathological characteristics in hepatocellular carcinoma. Methods: Expressions of SDF -1 and CXCR7 in 55 cases of hepatocellular carcinoma tissue and 28 cases of normal liver tissue were detected by immunohistochemical method. Results: Expressions of SDF -1 and CXCR7 were negative in normal liver tissues. Positive expression rates of SDF - 1 and CXCR7 in hepatocellular carcinoma were 63.6% and 78.2% .respectively. SDF -1 protein was expressed by oncocytes and mesenchyma epithelial cells. CXCR7 protein was expressed mainly by mesenchyma endothelial cell. Expression of SDF - 1 correlated with portal venous tumor emboli. Expression of CXCR7 correlated with lesions number and portal venous tumor emboli (P < 0.05 ). Conclusin: SDF -1 and CXCR7 take part in invasive progression and metastasis of hepatocellular carcinoma by promoting new blood vessel formation, and may be index of evaluating invasiveness and prognosis.%目的:研究趋化因子SDF -1及其受体CXCR7在肝细胞癌组织中的表达,探讨其表达水平与临床病理特征的关系.方法:采用SP免疫组织化学法检测55例肝细胞癌标本及28例正常肝组织标本中SDF -1、CXCR7的表达.结果:SDF -1、CXCR7在正常肝组织表达均阴性,癌组织中二者阳性表达率分别为63.6％和78.2％;SDF -1表达于癌细胞及间质上皮细胞,CXCR7主要表达于间质内皮细胞,SDF -1表达与门静脉癌栓有关,CXCR7表达与肝内病灶数目、门静脉癌栓有关.结论:SDF - 1/CXCR7生物学轴通过促进新生血管生成,参与肝细胞癌的侵袭和转移.有望成为判断肝细胞癌侵袭性及预后的指标.