iNOS/COX-2与恶性肿瘤

摘要

Inducible nitric oxide synthase ( iNOS ) and cyclooxygenase - 2 ( COX - 2 ) play important roles in carci-nogenesis, growth, invasion, metastasis, and prognosis. There is a positive relationship between iNOS and COX -2 in various malignancies. There is cross -talk between iNOS and COX -2. iNOS and COX -2 may become new anti-cancer targets if the further studies were done and these mechanisms were maken clear.%诱导型一氧化氮合酶(iNOS)和环氧合酶2(COX-2)均与肿瘤发生、生长、转移及预后有关.在许多恶性肿瘤组织中,两者的表达一致上调,呈正相关,二者的联合表达与肿瘤的生物学行为密切相关.本文综述了iNOS/COX-2与恶性肿瘤的关系,并提出以iNOS/COX-2 为靶点的恶性肿瘤治疗和研究的思路.